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过氧化物酶体增殖物激活受体亚型(PPAR-γ)是调节目标基因表达的核内受体转录因子超家族成员,参与调节代谢、细胞的增殖、分化和凋亡,在免疫系统中发挥着重要作用,与多种代谢性疾病和免疫性疾病的发生发展密切相关。近年来,随着对PPAR-γ研究的逐步深入,发现PPAR-γ在呼吸系统慢性疾病,如哮喘、慢性阻塞性肺病(COPD)、肺癌和肺纤维化的发病过程中起着重要的作用,PPAR-γ激动剂的应用有望成为治疗呼吸系统慢性疾病的一个新方法。
Peroxisome proliferator-activated receptor subtypes (PPAR-γ) are members of the nuclear receptor transcription factor superfamily that regulates the expression of a target gene and are involved in the regulation of metabolism, cell proliferation, differentiation and apoptosis, and in the immune system Play an important role, and a variety of metabolic diseases and immune diseases are closely related to the occurrence and development. In recent years, with the further study of PPAR-γ, PPAR-γ was found to play an important role in the pathogenesis of chronic respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), lung cancer and pulmonary fibrosis, The use of PPAR-γ agonists is expected to be a new approach to the treatment of chronic respiratory diseases.