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[目的]探讨白细胞介素-6与心脏黏液瘤的关系。[方法]用酶联免疫吸附试验(ELISA)检测30例心脏黏液瘤患者术前、术后1个月和术后3个月血清IL-6水平,并与40例健康者对照比较。[结果]心脏黏液瘤患者术前血清中IL-6水平明显高于对照组(P<0.001);术后1个月和术后3个月IL-6均降到正常水平,与对照组比较均无统计学差异(P>0.05)。Logistic回归分析发现,血沉增快、肿瘤大小与血清IL-6水平有显著性关联(P<0.05)。[结论]心脏黏液瘤患者血清IL-6水平升高,经手术治疗后可恢复正常。IL-6在心脏黏液瘤的发生、发展和治疗过程中具有重要意义。
[Objective] To investigate the relationship between interleukin-6 and cardiac myxoma. [Methods] Serum IL-6 levels in 30 patients with cardiac myxoma before operation, 1 month after operation and 3 months after operation were detected by enzyme-linked immunosorbent assay (ELISA) and compared with 40 healthy controls. [Results] The serum levels of IL-6 in the patients with cardiac myxoma were significantly higher than those in the control group (P<0.001). The IL-6 levels were decreased to normal level at 1 month and 3 months after operation, and compared with the control group. There was no statistical difference (P>0.05). Logistic regression analysis found that ESR was increased and tumor size was significantly associated with serum IL-6 levels (P<0.05). [Conclusion] The serum IL-6 level in patients with cardiac myxoma is increased and can return to normal after surgical treatment. IL-6 plays an important role in the occurrence, development and treatment of cardiac myxoma.