目的 :研究系统性红斑狼疮 (SLE)的心脏病变及其与狼疮活动的关系。方法 :96例SLE病人和 6 4例健康体检人员均行二维和多普勒超声心动图检查以及有关狼疮活动的临床和实验室指标检测。结果 :40例SLE病人合并有心脏病变 ,以瓣膜病变最常见 ,其次为心包积液、心肌病变。瓣膜病变中以二尖瓣增厚、瓣膜赘生物和瓣膜反流多见 ,合并瓣膜病变病人均无明显血流动力学障碍。心包积液多为轻～中度积液 ,临床无明显症状 ,重度积液只有3例。发生与结论 :SLE病人合并心脏病变常见 ,心脏瓣膜病变、心肌病变发生与否同狼疮活动无关 ,心包积液与SLE活动有关 Objective: To study the relationship between systemic lupus erythematosus (SLE) and heart disease and lupus activity. Methods: Sixty-six patients with SLE and 64 healthy individuals underwent two-dimensional and Doppler echocardiography and clinical and laboratory tests on lupus activity. Results: 40 cases of SLE patients with heart disease, valve disease is the most common, followed by pericardial effusion, myocardial lesions. Valvular lesions in the mitral valve thickened, valve neoplasms and valve regurgitation more common, valvular disease patients with no significant hemodynamic disorders. Pericardial effusion and mild to moderate effusion, clinical no obvious symptoms, severe effusion, only 3 cases. Occurrence and Conclusion: Common SLE patients with heart disease, heart valve disease, myocardial disease or not with the activity of lupus unrelated to pericardial effusion and SLE activity