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为明确黑木耳多糖的组分及其生理功能,以复合酶法对黑木耳多糖进行了提取,并以柱层析法对其进行了纯化;以纯化的黑木耳多糖喂饲大鼠,考察了其降血脂的功能。通过试验得到两种黑木耳多糖,即APE I和APE II;各剂量的APE I对大鼠体重没有显著影响;100mg/kg体重及以上的APE I可以显著降低高脂大鼠血清的TG、TC、LDL-C水平,提高其HDL-C水平;200mg/kg体重的黑木耳多糖对高脂大鼠血清的TG、TC、LDL-C和HDL-C的影响与70mg/kg体重的脂必妥的效果没有显著差异,并能够显著提高高脂血症大鼠的HDL-C/TC水平。黑木耳多糖(APE I)具有降血脂功能,对高脂血症的发生有一定的预防作用,同时对冠心病和动脉粥样硬化也有一定的预防作用。
In order to clarify the composition of black fungus polysaccharides and their physiological functions, polysaccharides were extracted from Auricularia auricula by complex enzymatic method and purified by column chromatography. The purified Auricularia auricular polysaccharide was fed to rats Its hypolipidemic function. Two kinds of Auricularia auricular polysaccharides, namely APE I and APE II, were obtained through experiments. There was no significant effect of APE I at each dose on the body weight of rats. APE I at 100 mg / kg body weight and above could significantly decrease TG, TC , LDL-C levels, to increase their HDL-C levels; 200mg / kg body weight of black fungus polysaccharide on serum triglyceride, TC, LDL-C and HDL-C and 70mg / kg body weight The effect was not significantly different, and can significantly improve the level of HDL-C / TC in hyperlipidemic rats. Black fungus polysaccharide (APE I) has a hypolipidemic effect on the occurrence of hyperlipidemia have a preventive effect, while coronary heart disease and atherosclerosis also have some preventive effect.