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目的 :明确直肠癌癌灶内静脉侵袭同肝转移的关系 ,探明癌灶内静脉侵袭对直肠癌肝转移的预测作用。方法 :随机选取本院1992年5月至1993年6月 ,54例直肠癌病例 ,取其手术切除标本 ,采用抗第Ⅷ因子免疫组织化学染色 ,对癌灶内的静脉侵袭加以判定 ,继之探讨静脉侵袭同肝转移的关系。本组肝转移病例包括术中探明的同时性肝转移4例及术后5年随访复查的异时性肝转移5例。结果 :静脉侵袭阳性V( +)组肝转移率为30.77 % ,静脉侵袭阴性组V( -)肝转移率为3.57 % ,两组间有极显著差异 ( χ2=7.18,P<0.01)。结论 :癌灶内的静脉侵袭同肝转移密切相关 ,静脉侵袭可作为预测肝转移的指标 ,对V( +)患者应加强术后监测和治疗
Objective: To clarify the relationship between vein invasion and liver metastasis in the foci of rectal cancer and to explore the predictive value of vein invasion in the foci on the liver metastasis of rectal cancer. Methods: From May 1992 to June 1993, 54 cases of rectal cancer were randomly selected from our hospital. Surgical resection specimens were collected. The anti-Ⅷ factor immunohistochemical staining was used to determine the vein invasion in the foci. To explore the relationship between vein invasion and liver metastasis. The group of liver metastases, including intraoperative evidence of simultaneous liver metastases in 4 cases and 5-year follow-up after resection of heterotopic liver metastases in 5 cases. Results: The hepatic metastasis rate was 30.77% in V + group and 3.57% in V + - negative group. There was a significant difference between the two groups (χ2 = 7.18, P <0.01). Conclusions: Intravenous invasion is closely related to hepatic metastasis. Intravenous invasion may be used as an index to predict liver metastasis. Postoperative monitoring and treatment should be strengthened in V (+) patients