恶性型黑棘皮病目前尚为一原因不明的严重疾病,其典型病变为皮肤粘膜极度增厚,可有色素增多,且伴发内脏腺癌,以胃癌为最多见。近来国内外关于本病的文献报告已较多。必须指出的是早在本病严重的全身症状出现之 Malignant acanthosis is currently a serious disease of unknown cause. Its typical lesions are extremely thickening of the skin and mucous membranes, may have increased pigmentation, and accompanied by visceral adenocarcinoma. Gastric cancer is the most common. Recently, there have been more reports on the disease at home and abroad. It must be pointed out that as early as the severe systemic symptoms of the disease appear