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目的:比较阿莫西林与阿莫西林-克拉维酸钾的不良反应。方法:选取药品不良反应监测中心数据库2014年2月至2015年2月上报的240例关于阿莫西林与阿莫西林-克拉维酸钾不良反应的报告,行回顾性分析,分别纳入对照组与观察组,各120例,对比两组药物的不良反应发生情况及对原患疾病的影响。结果:观察组的不良反应共发生567例次,对照组共发生212例次,两组前3位不良反应类型所占比重比较,差异有统计学意义(P<0.05);观察组的不良反应时间明显短于对照组(P<0.05);观察组的不良反应治愈率及对原患疾病无明显影响所占比重高于对照组(P<0.05)。结论:与阿莫西林相比,临床应用阿莫西林-克拉维酸钾,疗效显著。
Objective: To compare the adverse reactions of amoxicillin and amoxicillin-clavulanate potassium. METHODS: A total of 240 reports of adverse reactions of amoxicillin and amoxicillin-clavulanate reported from February 2014 to February 2015 were retrospectively analyzed and included in the control group and the control group The observation group, each 120 cases, compared the two groups of adverse drug reactions and the impact on the original disease. Results: A total of 567 adverse reactions occurred in the observation group, with 212 cases in the control group. There were significant differences in the proportions of the first three adverse reactions among the two groups (P <0.05), adverse reactions in the observation group The time was significantly shorter than that of the control group (P <0.05). The cure rate of the adverse reaction and the proportion of the patients with no obvious effect on the original disease were higher than those of the control group (P <0.05). Conclusion: Compared with amoxicillin, clinical application of amoxicillin - clavulanate potassium, a significant effect.