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本文作者研究一组伴有t(11;14)的低度异质性淋巴瘤,9例患者中男性8例,年龄32~72岁,平均65岁。确诊时患者均有骨髓受累的白血病血液征象和明显脾肿大,其中1例累及胃肠道,临床治疗效果差,5例4年内死亡。取患者送检的淋巴结或脾脏等标本作病理、细胞遗传学和分子生物学研究。病理学证实,患者淋巴结、脾正常结构消失,代之以大量不规则核,小~中等大小的淋巴瘤细
The authors studied a group of low-grade heterogeneous lymphomas with t(11;14). Among 9 patients, there were 8 males, aged 32-72 years with an average age of 65 years. At the time of diagnosis, the patients had bone marrow-associated leukemia blood signs and splenomegaly, of which one involved the gastrointestinal tract and clinical treatment was poor. Five patients died within 4 years. Specimens from the lymph nodes or spleen examined by the patient were taken for pathological, cytogenetic and molecular biological studies. Pathology confirmed that the normal structure of the patient’s lymph nodes and spleen disappeared, replaced by a large number of irregular nucleus, and small to medium-sized lymphomas were fine.