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目的:研究丹黄凝胶体外释药特性和体外经皮渗透性。方法:采用改良Franz扩散池,以大黄酚、小檗碱为评价指标,运用动力学模型描述指标成分在体外的释药规律和经皮渗透规律。结果:大黄酚以零级动力释放模型拟合优度最好,小檗碱以Ritger-Peppas模型拟合优度最好;大黄酚和小檗碱在体外皮肤均以一级动力学渗透吸收;大黄酚、小檗碱体外释药特性与经皮渗透性的相关方程分别为Y=0.468 7X+4.972 2(r=0.966 4),Y=0.666 9X+2.487 4(r=0.974 0),体外释放速率均>体外经皮速率。结论:大黄酚、小檗碱体外释药特性与经皮渗透性存在较好线性相关性。
OBJECTIVE: To study in vitro release characteristics and transdermal permeation of Dan Huang gel. Methods: The modified Franz diffusion cell was used to evaluate the release of index components and transdermal permeation rules by using the kinetic model with chrysophanol and berberine as evaluation indexes. Results: The best fit of chrysophanol with zero-order kinetic release model was the best. The best fit of berberine by Ritger-Peppas model was the best. Chrysophanol and berberine were absorbed by the first-order kinetics in vitro. The correlation equations of in vitro release characteristics and transdermal permeation of chrysophanol and berberine were Y = 0.468 7X + 4.972 2 (r = 0.966 4), Y = 0.666 9X + 2.487 4 (r = 0.974 0) Rate> In vitro transdermal rate. Conclusion: There is a good linear correlation between in vitro release characteristics of chrysophanol and berberine and transdermal permeability.