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目的 验证新剂型阿苯达唑乳剂对肝囊型包虫病患者的临床疗效。方法 对 2 12例肝囊型包虫病患者用阿苯达唑 10mg/Kg/d和 12 5mg/Kg/d两种剂量进行治疗。服药 3个月复查一次为一个疗程 ,各疗程之间不间断连续用药。以B超影象特征为主判定疗效。观察不同疗程的效果。以停药时的检查结果为近期疗效。停药后随访 1- 4年的结果为远期疗效。结果 两个剂量组共 2 12例患者的平均近期疗效为 :治愈率 74 5 % ,有效率为 99 1% ,无效率为 0 9%。平均远期疗效为 :治愈率为 83 1% ,有效率为 89 3% ,无效率为 0 6% ,复发率为 10 2 %。以 12 5mg/Kg/d连续治疗 9个月的疗效最好。复发病人再治疗的效果良好。结论 阿苯达唑乳剂对肝囊型包虫病的临床疗效超过当前包虫病药物治疗的最好水平。且疗效稳定可靠 ,不良反应轻微。可做为包虫病首选治疗方法。
Objective To verify the clinical effect of albendazole emulsion on patients with hepatic cystic echinococcosis. Methods Two hundred and twelve patients with cystic echinococcosis were treated with albendazole 10mg / Kg / d and 125mg / Kg / d. Medication for 3 months to review once for a course of treatment, continuous treatment of non-stop medication. To B-based imaging features to determine the main effect. Observe the effect of different courses. To stop the test results for the near future effect. Follow-up 1-4 years after stopping the results for the long-term efficacy. Results The average short-term efficacy of 2 12 patients in two dose groups was 74 5%, 99 1% and 0 9%, respectively. The average long-term efficacy was 83 1%, 89 3%, 0 6%, and 10 2% respectively. Continuous treatment of 12 5mg / Kg / d for 9 months the best effect. Recurrent patients re-treatment effect is good. Conclusion The clinical efficacy of albendazole emulsion in the treatment of hepatic cystic echinococcosis exceeds the current best level of medical treatment of hydatid disease. The effect is stable and reliable, minor adverse reactions. Hydatid disease can be used as the preferred treatment.