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本文旨存就白介素-6(IL-6)和C反应蛋白(CRP)升高对老年人死亡率的预测价值进行了评估。 675例老人,男279例,女396例,均龄77.8±3.2岁。研究中采其静脉血测定IL-6和CRP水平。嗣后人均随访4.6年,观察分析IL-6及CRP与老年人死亡率间的关系。 675例老人中,吸烟者29％,伴心血管病或糖尿病史者18％。随访期间共有176例不幸死亡。分析显示,男性、吸烟、体重指数、糖尿病及心血管病史皆与IL-6和CPR正相关;抗炎药及抗氧化剂与之逆相关;饮酒及肿瘤史与之不相关。在IL-6及CRP同时升高者,血中纤维蛋白原较高(P=0.0001)、白细胞总数较高(P=0.0001)、白蛋白计量较低(P=0.0001)。统计分析表明,在人为划分的IL-6或CRP不同水平4亚组,其总死亡率及
The purpose of this paper is to evaluate the predictive value of elevated interleukin-6 (IL-6) and C-reactive protein (CRP) in senile mortality. 675 elderly people, 279 males and 396 females, mean age 77.8 ± 3.2 years. Venous blood was collected during the study to determine IL-6 and CRP levels. After a follow-up of 4.6 years, the relationship between IL-6 and CRP and the mortality of the elderly was observed and analyzed. Of the 675 elderly people, 29% smoke smokers, with a history of cardiovascular disease or diabetes 18%. A total of 176 unfortunate deaths occurred during follow-up. Analysis showed that male, smoking, body mass index, diabetes and cardiovascular history were positively correlated with IL-6 and CPR; anti-inflammatory drugs and antioxidants inversely related; alcohol and tumor history and not related. High levels of fibrinogen (P = 0.0001), higher total leukocytes (P = 0.0001) and lower albumin (P = 0.0001) were observed in patients with elevated IL-6 and CRP. Statistical analysis showed that in the artificial division of IL-6 or CRP levels 4 subgroups, the total mortality and