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目的探讨轻症支气管肺炎急性期IL-6在早期鉴别支原体肺炎中的意义。方法收集宁波市鄞州人民医院儿科2011年1月—2012年6月收治的轻症支气管肺炎患儿137例,其中支原体肺炎患儿62例,作为观察组,非支原体肺炎患儿75例,作为对照组,健康体检儿童30例,作为健康体检组。所有研究对象分别检查血常规、CRP、IL-6及相关临床指标,回顾性分析各组患儿的IL-6、CRP情况。结果所有患儿中支原体肺炎的发病率为45.26%。急性期支原体肺炎患儿IL-6水平较非支原体肺炎及健康体检组明显升高(P<0.05),急性期支原体肺炎CRP阳性患儿血清IL-6水平明显高于非支原体肺炎组CRP阳性患儿(P<0.05),急性期支原体肺炎CRP阴性患儿血清IL-6水平与非支原体肺炎组CRP阴性患儿间差异无统计学意义(P>0.05)。结论急性期入院的轻症肺炎患儿中若IL-6明显增高,则支原体感染的可能性大,若伴CRP同步增高则往往可以临床诊断支原体肺炎。
Objective To investigate the significance of IL-6 in the early stage of mycoplasma pneumoniae of mild bronchopneumonia. Methods A total of 137 children with mild bronchopneumonia admitted in Ningbo Yinzhou People’s Hospital from January 2011 to June 2012 were enrolled. Among them, 62 cases were children with mycoplasmal pneumonia, and 75 children with non-mycoplasmal pneumonia as observation group. Group, 30 healthy children, as a physical examination group. All subjects were examined blood, CRP, IL-6 and related clinical indicators, retrospective analysis of children with IL-6, CRP. Results The incidence of mycoplasma pneumonia in all children was 45.26%. IL-6 levels in children with acute mycoplasmal pneumonia were significantly higher than those in non-mycoplasmal pneumonia and healthy subjects (P <0.05). The serum level of IL-6 in CRP-positive children with acute mycoplasmal pneumonia was significantly higher than that in non-mycoplasmal pneumonia (P <0.05). There was no significant difference between serum IL-6 levels in CRP-negative children with acute mycoplasmal pneumonia and non-mycoplasmal pneumonia patients with CRP-negative children (P> 0.05). Conclusions Mycoplasma pneumonia is more likely to be infected if mild IL-6 is present in children with acute pneumonia admitted in acute phase. If the CRP is increased synchronously, mycoplasma pneumonia may be clinically diagnosed.