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目的 研究对苯二甲酸 (TPA)、乙二醇 (EG)、联苯 -联苯醚 (DOW )对职业人群肝肾损伤的影响 ,寻找作业工人健康监护的早期指标。方法 采用职业流行病学的方法 ,在对某化纤公司进行劳动卫生学调查的基础上 ,分析TPA、EG、DOW接触工人肝肾功能的变化。结果 TPA +EG +DOW接触组男工的血清γ 谷氨酰转肽酶 (GGT)活力和总胆汁酸 (TBA)的含量分别为 (35 .45±16 .0 9)U/L、(10 .2 9± 6 .76 ) μmol/L ,女工的血清丙氨酸转氨酶 (ALT)活力和TBA含量分别为(30 .6 8± 8.5 8)U/L、(9.5 3± 6 .6 3) μmol/L ,均不同程度地高于对照组、TPA接触组和DOW接触组 ,且差异有显著性 (P <0 .0 5、P <0 .0 1) ;TPA +EG +DOW接触组尿N 乙酰 β D 氨基葡萄糖苷酶 (NAG)活力和 β2 微球蛋白 (β2 MG)含量与对照组、TPA接触组和DOW接触组相比 ,差异有显著性 (P <0 .0 5、P<0 .0 1) ,男工为 (5 .6 8± 4.0 1)U/mmolCr与 (2 3.49± 13.44 )mg/molCr;女工为 (6 .6 8± 4.6 8)U/mmolCr与 (2 2 .80± 13.0 0 )mg/molCr。经多元回归分析 ,控制了性别、吸烟、饮酒等混杂因素 ,接触不同的毒物与作业工人肝肾损伤的关系有显著性 (P <0 .0 0 1)。结论 TPA、EG、DOW对职业人群的肝肾损伤存在联合作用 ,建议血清ALT、GGT、TBA、尿NAG和
Objective To study the effects of TPA, EG and DOW on occupational liver and kidney injury and to find the early indicators of occupational health monitoring. Methods The occupational epidemiology method was used to analyze the changes of liver and kidney function of workers exposed to TPA, EG and DOW based on the investigation of labor hygiene of a chemical fiber company. Results The levels of serum GGT and total bile acid (TBA) in TPA + EG + DOW exposure group were (35.45 ± 16.90) U / L and (10 (29.8 ± 8.58) U / L, (9.53 ± 6.36) and (29.3 ± 6.36) μmol / L, respectively. The levels of ALT and TBA in female workers were μmol / L, all of which were higher than that of the control group, TPA contact group and DOW exposure group to a certain extent (P <0.05, P <0.01); TPA + EG + DOW contact group urine N acetylated β D glucosaminidase (NAG) activity and β2 microglobulin (β2 MG) content compared with the control group, TPA contact group and DOW exposure group, the difference was significant (P <0. 05, P < (6.08 ± 4.01) U / mmolCr and (2.49 ± 13.44) mg / molCr for male workers and (6.68 ± 4.68) U / mmolCr and (2 2 .80 ± 13.0 0) mg / molCr. By multivariate regression analysis, the factors such as gender, smoking, drinking and other factors were controlled. There was a significant relationship between exposure to different toxicants and liver and kidney injury in workers (P <0.01). Conclusion TPA, EG and DOW have a combined effect on liver and kidney injury in occupational population. It is suggested that serum ALT, GGT, TBA, urinary NAG and