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目的 探讨心康口服液预防小鼠柯萨奇B3病毒性心肌炎的作用。方法 心康口服液预防性用药 2d后的小鼠经腹腔感染CVB3 ,以诱发急性病毒性心肌炎模型 ,持续用药至 2 0d ,观察小鼠于感染不同阶段的心肌组织形态学改变并进行形态定量分析 ,所得数据用SPSS PC软件包作统计学处理。结果 心康口服液各剂量组的心脏表面重度病变检出率显著低于病毒对照组 (P <0 0 1) ;心肌组织重度损伤 (心肌细胞大片坏死崩解 )的检出率均低于病毒组及干扰素组 ,其中中剂量组与病毒组差异显著 (P <0 0 1) ;心肌平均病变面积、病变面积 全心面积比值第 2 0d时心康组与干扰素组均与病毒组差异显著 (P <0 0 1) ,第 5d时心康各剂量组与病毒组差异显著 (P <0 0 1)。结论 心康口服液预防性给药可保护心肌 ,减轻心肌损伤及促进损伤心肌恢复 ,其预防柯萨奇B3病毒性心肌炎的作用类似干扰素。
Objective To investigate the effect of Xinkang Oral Liquid on preventing Coxsackie B3 viral myocarditis in mice. Methods The mice infected with Xinkang Oral Liquid for 2 days were infected intraperitoneally with CVB3 to induce acute viral myocarditis. The drug was continued for 20 days. Morphological changes of myocardium at different stages of infection were observed and morphometric analysis was performed. The data obtained were statistically processed using the SPSS PC software package. Results The detection rate of cardiac surface lesions in Xinkang Oral Solution was significantly lower than that in virus control group (P < 0.01). The detection rate of severe myocardial tissue damage (myocardial cell necrosis and disintegration) was lower than that of virus. In the interferon group and the interferon group, the difference between the middle dose group and the virus group was significant (P < 0.01); the mean lesion area of the myocardium and the ratio of the whole heart area of the lesion area on the 20th day were different between the Xinkang and interferon groups and the virus group. Significantly (P <0 01), on the 5th day Xin Kang dose groups and virus groups were significantly different (P <0 01). Conclusion Prophylactic administration of Xinkang Oral Liquid can protect the myocardium, reduce myocardial injury and promote the recovery of damaged myocardium. Its preventive effect against Coxsackie B3 viral myocarditis is similar to interferon.