因子Ⅷ相关蛋白(Von Willebrand因子,以下简称VWF)不仅是凝血过程中重要因子Ⅷ:C的载体,而且在血小板与血管壁相互作用的初期止血过程中起着粘附蛋白的作用。缺损者为血管性假血友病,它是一种较常见的出血性疾病。我院血栓与止血研究室在国内首次获得了一组分泌抗人VWF单克隆抗体小鼠杂交瘤细胞,并对其中三株分泌的单克隆抗体进行了有关的免疫学、生物化学和血液学研究。 Von Willebrand factor (VWF) is not only a carrier of important factor Ⅷ: C during coagulation, but also acts as an adhesion protein during the initial hemostasis of platelet-vessel wall interaction. The defect is von Willebrand disease, which is a more common bleeding disorder. For the first time in China, a thrombosis and hemostasis laboratory in our hospital obtained a group of mouse hybridoma cells secreting anti-human VWF monoclonal antibody and conducted relevant immunological, biochemical and hematological studies on the three secreted monoclonal antibodies .