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目的观察连续性血液净化(Continuous blood purification,CBP)治疗糖尿病肾病相关重症并发症的临床疗效。方法21例2型糖尿病肾病患者中均有顽固性水肿,经内科保守治疗无效,另外6例糖尿病肾病酮症酸中毒患者,均有不同程度的肾功能不全、电解质紊乱及脱水症状,27例患者均行CBP治疗,分别比较前21例患者CBP治疗前后BUN、SCr、TCO2、GLU、UA、K+、Na+变化及后6例CBP治疗前后BUN、SCr、GLU、K+、Na+、MOMS变化。结果前21例患者经CBP治疗后肾功能显著改善(P<0.01-0.05)、水肿明显消退,透析中血压、血糖保持稳定;后6例患者肾功能恢复正常(P<0.05)、酸碱失衡及电解质紊乱完全纠正,血糖控制良好。结论合理使用CBP治疗糖尿病肾病相关重症并发症,疗效显著,值得临床推广应用。
Objective To observe the clinical efficacy of continuous blood purification (CBP) in the treatment of severe complications associated with diabetic nephropathy. Methods Twenty-one patients with type 2 diabetic nephropathy had intractable edema, which were ineffective after conservative treatment. In addition, 6 patients with diabetic nephropathy had renal insufficiency, electrolyte imbalance and dehydration, and 27 patients The changes of BUN, SCr, GLU, KA, Na +, MOMS before and after CBP treatment were compared between the two groups before and after CBP treatment. Results In the first 21 cases, the renal function was significantly improved after CBP treatment (P <0.01-0.05). Edema was subsided obviously. Blood pressure and blood glucose remained stable during dialysis. The renal function of the latter 6 cases returned to normal (P <0.05) And electrolyte disorders completely corrected, good glycemic control. Conclusion The rational use of CBP in the treatment of diabetic nephropathy related to severe complications, the effect is significant, worthy of clinical application.