论文部分内容阅读
耐药是白血病化疗失败的主要原因。甲磺酸伊马替尼在慢性粒细胞白血病的治疗中取得了良好的疗效。然而,随着伊马替尼的广泛应用,白血病细胞针对伊马替尼的耐药越来越多,极大地限制了它的临床应用。目前研究认为,伊马替尼耐药是一个复杂的多因素作用的结果,许多逆转耐药性的方法正在深入研究。现就其耐药的主要机制及逆转耐药发生的策略进行综述。
Drug resistance is the main reason for the failure of chemotherapy for leukemia. Imatinib mesylate in the treatment of chronic myeloid leukemia achieved good results. However, with the extensive use of imatinib, the resistance of leukemic cells to imatinib is increasing, which greatly limits its clinical application. Current research suggests that imatinib resistance is the result of a complex multifactorial effect and many methods of reversing drug resistance are being explored. Now the main mechanism of its resistance and strategies to reverse the emergence of resistance are reviewed.