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目的研究蛛网膜下腔出血患者外周血血小板平均体积(mean platelet volume,MPV)、计数的动态变化,探讨其可能的临床意义。方法 2011年1月-2012年12月在扬州市第一人民医院同期住院的蛛网膜下腔出血、急性脑梗死患者,蛛网膜下腔出血组25例,急性脑梗死组45例,老年对照组40例。患者于入院后第2天早晨7:00肘静脉抽血3 ml,查MPV、血小板计数(platelet,Plt)、血小板分布宽度(platelet distribution width,PDW)。计量资料采用t检验,P<0.05为差异有统计学意义。结果蛛网膜下腔出血组、急性脑梗死组、老年对照组MPV[(10.21±3.15)、(13.44±1.39)、(11.70±1.70)f/L]、Plt[(148.54±39.48)×109/L、(100.66±52.51)×109/L、(131.00±45.50)×109/L]比较差异均有统计学意义(均P<0.05),蛛网膜下腔出血组MPV、Plt发病后2、3周[(11.94±2.18)、(12.00±1.98)f/L、(132.09±40.75)×109/L、(125.54±35.08)×109/L]与发病1 d[(10.21±3.15)f/L、(148.54±39.48)×109/L]比较差异均有统计学意义(均P<0.05)。结论蛛网膜下腔出血后血小板计数和体积的变化可能与急性应激状态有关。
Objective To study the dynamic changes of mean platelet volume (MPV) and count in peripheral blood of patients with subarachnoid hemorrhage and to explore its possible clinical significance. Methods From January 2011 to December 2012, 25 patients with subarachnoid hemorrhage, 25 patients with subarachnoid hemorrhage, 45 patients with acute cerebral infarction, elderly control group 40 cases. Patients on the second day after admission at 7:00 in the elbow venous blood 3 ml, check MPV, platelet count (Plt), platelet distribution width (PDW). Measurement data using t test, P <0.05 for the difference was statistically significant. Results The levels of MPV in subarachnoid hemorrhage group, acute cerebral infarction group and elderly control group were significantly higher than those in control group (MPV [(10.21 ± 3.15), (13.44 ± 1.39), (11.70 ± 1.70) f / L] and Plt [(148.54 ± 39.48) L, (100.66 ± 52.51) × 109 / L, (131.00 ± 45.50) × 109 / L] were significantly different (all P <0.05). Subarachnoid hemorrhage group MPV, (11.94 ± 2.18), (12.00 ± 1.98) f / L, (132.09 ± 40.75) × 109 / L, (125.54 ± 35.08) × 109 / L] , (148.54 ± 39.48) × 109 / L] were significantly different (all P <0.05). Conclusion The change of platelet count and volume after subarachnoid hemorrhage may be related to the state of acute stress.