论文部分内容阅读
目的探讨腹腔镜术后联合达菲林或孕三烯酮治疗卵巢巧克力囊肿的临床疗效。方法选取福建医科大学附属福建省妇幼保健院妇科2013年1月—2015年3月收治的卵巢巧克力囊肿患者120例为研究对象。所有患者按治疗方法不同随机分为对照组A、观察组B和观察组C,各40例。对照组A患者予以单纯腹腔镜手术治疗,观察组B患者腹腔镜术后予以达菲林治疗,连续治疗3个月,观察组B患者腹腔镜术后予以孕三烯酮治疗,连续治疗3个月。比较3组患者血清雌二醇(E2)表达水平、临床疗效、随访2年合并不孕患者受孕率。结果治疗前3组患者E2水平比较,差异无统计学意义(P>0.05)。治疗后3组患者E2水平比较,差异有统计学意义(P<0.05);治疗后观察组B、C患者E2水平低于对照组A(P<0.05);观察组B患者E2水平低于观察组C(P<0.05)。治疗后3组患者E2水平低于治疗前(P<0.05)。3组患者临床疗效比较,差异有统计学意义(P<0.05)。观察组B、C总有效率高于对照组A(P<0.05);观察组B和观察组C总有效率比较,差异无统计学意义(P>0.05)。3组患者复发率比较,差异有统计学意义(P<0.05)。观察组B、C复发率低于对照组A(P<0.05);观察组B和观察组C复发率比较,差异无统计学意义(P>0.05)。观察组B、C受孕率高于对照组A(P<0.05);观察组B和观察组C受孕率比较,差异无统计学意义(P>0.05)。结论腹腔镜术后联合达菲林或孕三烯酮治疗卵巢巧克力囊肿的临床疗效优于单纯腹腔镜手术,其可有效降低E2水平,提高疗效和受孕率,减少复发率。
Objective To investigate the clinical efficacy of lafentanal combined with daphnilin or gestrinone in treatment of ovarian chocolate cyst. Methods A total of 120 patients with ovarian chocolate cyst admitted to Fujian Maternal and Child Health Hospital Affiliated to Fujian Medical University from January 2013 to March 2015 were selected as the research object. All patients were randomly divided into control group A, observation group B and observation group C, 40 cases in each group. Control group A patients were treated with laparoscopic surgery alone, observation group B patients laparoscopic surgery to Tamiflun treatment, continuous treatment for 3 months, observation group B patients received gestrinone after laparoscopic treatment, continuous treatment for 3 months . The level of serum estradiol (E2) expression was compared between the three groups. The clinical efficacy and conception rate of 2-year follow-up infertility patients were compared. Results There was no significant difference in E2 level between the three groups before treatment (P> 0.05). After treatment, the levels of E2 in three groups were significantly different (P <0.05); after treatment, the levels of E2 in observation group B and C were lower than those in control group A (P <0.05); E2 in observation group B was lower than that in observation group Group C (P <0.05). After treatment, E2 levels in three groups were lower than before treatment (P <0.05). The clinical efficacy of three groups of patients, the difference was statistically significant (P <0.05). The total effective rate of observation group B and C was higher than that of control group A (P <0.05). There was no significant difference in the total effective rate of observation group B and observation group C (P> 0.05). The recurrence rate in 3 groups was statistically significant (P <0.05). The recurrence rate of observation group B and C was lower than that of control group A (P <0.05). There was no significant difference in the recurrence rate between observation group B and observation group C (P> 0.05). The pregnancy rate of observation group B and C was higher than that of control group A (P <0.05). There was no significant difference in the pregnancy rate between observation group B and observation group C (P> 0.05). Conclusions Laparoscopy combined with daphnilin or gestrinone in the treatment of ovarian chocolate cysts is better than simple laparoscopic surgery, which can effectively reduce the E2 level and improve the efficacy and pregnancy rate and reduce the recurrence rate.