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目的研究中性粒细胞淋巴细胞比值(NLR)是否可作为非酒精性脂肪性肝病(NAFLD)临床诊断及监测的有效指标。方法选取107例临床明确诊断为NAFLD且未经过药物治疗的患者作为病例组,同时选取106例年龄及性别匹配的健康受试者作为对照组。检测外周血血常规并计算NLR。结果病例组体质量指数(BMI)为(25.99±3.35)kg/m~2,高于对照组的(22.47±2.33)kg/m~2,差异有统计学意义(P<0.05)。病例组外周血谷丙转氨酶(ALT)、白细胞(WBC)计数、中性粒细胞(N)计数、NLR平均值及标准差分别为(48.37±27.84)U/L、(6.09±1.42)×10~9/L、(3.47±1.06)×10~9/L、(1.84±0.68),显著高于对照组(29.57±18.61)U/L、(5.64±1.30)×10~9/L、(3.09±0.96)×10~9/L、(1.63±0.66),差异有统计学意义(P=0.000、0.046、0.007、0.005<0.05)。NLR的曲线下的面积为0.791,相应的95%置信区间0.706,0.876,当cutoff值取1.63时,敏感性为79.6%,特异性为69%。结论 NLR可能用于NAFLD患者诊断及肝功能损害预测,具有较高的特异性及敏感性。
Objective To investigate whether neutrophil lymphocyte ratio (NLR) can be used as an effective indicator in the clinical diagnosis and monitoring of non-alcoholic fatty liver disease (NAFLD). Methods A total of 107 patients with clinically diagnosed NAFLD without drug treatment were enrolled as the case group, and 106 healthy subjects of the same age and gender were selected as the control group. Peripheral blood tests were performed and NLR was calculated. Results The body mass index (BMI) was (25.99 ± 3.35) kg / m ~ 2 higher than that of the control group (22.47 ± 2.33) kg / m ~ 2, the difference was statistically significant (P <0.05). The ALT, WBC count, neutrophil count, NLR mean and standard deviation were (48.37 ± 27.84) U / L and (6.09 ± 1.42) × 10 L, (3.47 ± 1.06) × 10 ~ 9 / L and (1.84 ± 0.68), respectively, which was significantly higher than that of the control group (29.57 ± 18.61 U / L, 5.64 ± 1.30 × 10-9 / L, 3.09 ± 0.96) × 10 ~ 9 / L, (1.63 ± 0.66), the difference was statistically significant (P = 0.000,0.046,0.007,0.005 <0.05). The area under the curve of NLR was 0.791, corresponding to a 95% confidence interval of 0.706, 0.876. When the cutoff value was taken as 1.63, the sensitivity was 79.6% and the specificity was 69%. Conclusion NLR may be used in the diagnosis of NAFLD and the prediction of liver damage, with high specificity and sensitivity.