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片仔癀由田七、蛇胆、麝香、牛黄等药组成。药理研究结果表明,具有:(1)镇痛作用:能明显抑制冰醋酸引起的扭体反应;延长热板引起的痛反应潜伏期。(2)抗炎作用:能明显抑制小鼠因二甲苯引起的耳肿胀以及角叉菜胶引起的足关节肿胀;而且能抑制腹膜炎性渗出。(3)镇静作用:大剂量2.4g/Kg显示镇静作用。(4)解痉作用:能抑制小鼠胃肠道推进。(5)抗缺氧作用明显。(6)有明显的抗高温作用。(7)能明显缩短凝血时间和凝血酶原时间。(8)毒性试验:大剂量连续给药一个月,小鼠未出现毒副作用。
Pien Tze Huang consists of Tian Qi, snake gall, musk, bezoar and other drugs. Pharmacological studies have shown that: (1) analgesic effect: can significantly inhibit the acetic acid-induced writhing reaction; prolong the latency of thermal reaction caused by hot plate. (2) Anti-inflammatory action: It can significantly inhibit mouse ear swelling caused by xylene and foot joint swelling caused by carrageenan; and it can inhibit peritonitis inflammatory exudation. (3) Sedation: Large doses of 2.4 g/Kg show sedation. (4) Antispasmodic effect: It can inhibit the promotion of gastrointestinal tract in mice. (5) Obvious anti-hypoxia effect. (6) Obvious anti-high temperature effect. (7) can significantly shorten the clotting time and prothrombin time. (8) Toxicity test: Large-dose continuous administration for one month did not show toxic side effects in mice.