全反式维Ａ酸被广泛认为对皮肤的光损害有修复作用。某些α-羟酸对光老化的皮肤有益。但至今尚无文献记载有关比较维Ａ酸与α-或β-羟酸短期治疗的研究。现采用随机双盲、安慰剂对照试验。 2 4例女性患者志愿者被随机均分 3组 ,分别应用 3种试验药物 :0 0 5 %全反式维Ａ酸 (Ｒ All-trans retinoic acid is widely believed to repair the photodamage of the skin. Some alpha-hydroxy acids are good for photo-aged skin. However, no literature has so far been written about the comparison of short-term treatment with retinoids and alpha- or beta-hydroxy acids. A randomized, double-blind, placebo-controlled trial is now available. Twenty-four female volunteers were randomly assigned to three groups, with three test drugs: 0 05% all-trans retinoic acid (R