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维生素B_1(VB_1)是许多动物的重要的饮食成分,它的焦磷酸酯以辅酶的形式参与羧化酶的组成而催化丙酮酸及其它α-酮酸的脱羧反应。已发现某些二价金属离子能显著提高VB_1的催化活性。但迄今为止,人们对金属离子在VB_1催化过程中所起的作用尚不十分清楚。目前已见报道的VB_1与金属形成的化合物只有两种类型:离子型复盐(Cu(Ⅱ))与
Vitamin B_1 (VB_1) is an important dietary component of many animals. Its pyrophosphate ester participates in the formation of carboxylase as a coenzyme to catalyze the decarboxylation of pyruvate and other α-keto acids. It has been found that certain divalent metal ions can significantly increase the catalytic activity of VB_1. But so far, the role of metal ions in the VB_1 catalysis has not been fully understood. So far, it has been reported that there are only two types of compounds formed by VB_1 and metal: ionic double salt (Cu (Ⅱ)) and