目的探讨南通市中老年骨质疏松(OP)患病率和高危人群发生率及影响因素。方法按照分层整群随机抽样原则,从南通市主城区10个街道中随机抽取3个街道,抽中的街道随机抽取1个社区居委会,每个社区居委会抽取600例40岁以上中老年常住人口。采用江苏省疾控中心统一印制的OP高危人群筛查表进行问卷调查并测量骨密度。结果 OP患者自报率为2.6%,男女分别为1.8%和3.0%。根据OP 1 min测试题,发现高危人群检出率为37.9%,男女分别为45.5%和33.6%,差异显著(χ~2=24.925,P<0.001)。骨密度筛查结果显示,骨量低下率、OP率分别为26.9%和12.8%。OP风险评估综合骨密度筛查的结果显示,OP总检出率和高危人群总检出率分别为14.7%和47.9%,男女差异显著(P<0.01)。随着年龄的增长,OP总检出率和高危人群总检出率呈明显上升趋势(P<0.01)。OP的影响因素Logistic回归分析显示,性别、年龄和不经常户外活动与OP发病关系密切(P<0.01)。结论早期发现、早期诊断、早期干预和早期治疗对防治中老年人群OP有重要意义。 Objective To investigate the prevalence of osteoporosis (OP) and the prevalence and influencing factors of middle-aged and elderly people in Nantong City. Methods According to the principle of stratified cluster random sampling, three streets were randomly selected from 10 streets in the main urban area of ​​Nantong City. One neighborhood committee was randomly selected from the streets in the district, and 600 community residents aged over 40 were drawn from each neighborhood committee . A questionnaire survey was conducted by using the screening list of at-risk population of OP in Jiangsu Province CDC. The BMD was measured. Results The self-report rate of OP patients was 2.6%, men and women were 1.8% and 3.0% respectively. According to the OP 1 min test, the detection rate was 37.9% in high-risk groups, with a significant difference of 45.5% and 33.6% for men and women (χ ~ 2 = 24.925, P <0.001). Bone mineral density screening results showed that the bone loss rate, OP rate were 26.9% and 12.8%. OP risk assessment comprehensive bone mineral density screening results showed that the total detection rate of OP and high-risk groups were 14.7% and 47.9%, respectively, significant difference between men and women (P <0.01). With the increase of age, the total detection rate of OP and the total detection rate of high-risk groups showed a clear upward trend (P <0.01). Influential factors of OP Logistic regression analysis showed that sex, age and infrequent outdoor activities were closely related to the pathogenesis of OP (P <0.01). Conclusion Early detection, early diagnosis, early intervention and early treatment of OP in the prevention and treatment of the elderly is of great significance.