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作为肝脏特异性化学元素锰应用在磁共振成像中,目前是通过静脉内给药。通过营养性促进因子,可以增加胃肠道锰的摄入。研究中的102只小鼠,其中6只小鼠作为对照组,其他小鼠均给予氯化锰,同时给予几种不同浓度的促进因子(维生素D3和丙氨酸),口服3 h后处死小鼠,取出心脏、肝脏和肾脏。通过原子吸收的方法测定锰浓度。结果发现肾脏和心脏锰浓度没有增加,而肝脏锰浓度增加显著(约100%),且无不良反应。研究认为给禁食小鼠增加胃肠道锰的摄入,可以增加肝脏锰浓度。
As a liver-specific chemical element manganese used in magnetic resonance imaging, intravenous administration is currently used. Through the nutritional promotion factor, can increase gastrointestinal manganese intake. Of the 102 mice in the study, 6 mice were used as control group, and other mice were given manganese chloride with several different promotion factors (vitamin D3 and alanine) at the same time. After 3 hours of oral administration, mice were sacrificed Rat, remove heart, liver and kidneys. The concentration of manganese was determined by atomic absorption. The results showed no increase in kidney and heart manganese concentrations, but a significant (~ 100%) increase in hepatic Mn concentrations with no adverse reactions. Studies suggest that increasing fasting mice intake of gastrointestinal manganese can increase the concentration of manganese in the liver.