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目的:探讨大黄总游离蒽醌对慢性肾功能衰竭(CRF)大鼠的药效作用。方法:选择5/6肾切除复制慢性肾功能衰竭大鼠模型,给予大黄总游离蒽醌灌胃,观察大鼠一般情况、体重改变、血清BUN、Cr变化以及残肾的病理改变。结果:60 mg/kg、30mg/kg大黄总游离蒽醌灌胃给药4周后,大鼠血清BUN、Cr较模型对照组明显降低;残肾肾小管以及肾小球数量比较模型对照组明显增加;残肾肾小球平均面积、周长、最大直径、最小直径、肾小球基底膜(GBM)以及系膜平均面积、积分光密度值较模型对照组明显减小。结论:大黄总游离蒽醌能降低CRF大鼠血清BUN、Cr水平,抑制残余肾组织的纤维化和代偿性增生和肥大,改善肾小管硬化程度,抑制系膜细胞增生和细胞外基质的积聚,延缓大鼠慢性肾功能衰竭的进程。
Objective: To investigate the pharmacodynamic effects of rhubarb total free lanthanum on rats with chronic renal failure (CRF). METHODS: After 5/6 nephrectomy was performed to replicate chronic renal failure rat model, total rhizome of free rhubarb was given intragastrically. The general condition, body weight, changes of serum BUN and Cr, and pathological changes of residual kidney were observed. RESULTS: After administration of 60 mg/kg and 30 mg/kg rhubarb total gavage for 4 weeks, serum BUN and Cr were significantly lower than those in the model control group; the number of renal tubulars and glomeruli in the residual kidney was significantly higher in the control group than in the control group. The mean area, perimeter, maximum diameter, minimum diameter, glomerular basement membrane (GBM), average mesangial area, and integrated optical density of residual renal glomerulus were significantly reduced compared with the model control group. Conclusion: Rhubarb can reduce the serum levels of BUN and Cr in CRF rats, inhibit the fibrosis and compensatory hyperplasia and hypertrophy of residual renal tissues, improve the degree of renal tubular sclerosis, inhibit the proliferation of mesangial cells and the accumulation of extracellular matrix. Delays the progression of chronic renal failure in rats.