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目的:初步探讨茵山莲综合免疫疗法对ANP继发感染的治疗作用。方法:肠道菌群检测和免疫组化,放射免疫分析法研究了ANP模型肠道菌群变化和肠道局部免疫的变化,在此基础上进一步对严格按标准选入的SAP病人,采用中药茵山莲及微生态制剂综合疗法分别在临床表现,生化及血清内毒素,肠道局部免疫与细菌易位等方面进行对比研究。结果:ANP肠道膜菌群生物屏障受到破坏,G—肠杆菌是急性重症胰腺炎内源性感染的主要原因菌。综合免疫疗法治疗后1周及2周的生化指标及血清内毒素水平降低均优于常规组。结论:初步表明综合疗法能减轻或消除ANP继发感染临床表现,缩短感染持续时间。
Objective: To investigate the therapeutic effect of Yin mountain lotion comprehensive immunotherapy on the secondary infection of ANP. Methods: Intestinal flora detection and immunohistochemistry, radioimmunoassay were used to study the change of intestinal flora and intestinal immune in ANP model. On the basis of this, Yin mountain lotus and probiotics comprehensive treatment in clinical manifestations, biochemical and serum endotoxin, intestinal immune and bacterial translocation and other aspects of comparative study. Results: The biological barrier of ANP intestinal flora was destroyed. G-Enterobacter was the main cause of endogenous infection in acute severe pancreatitis. The biochemical indexes and the level of serum endotoxin in the first week and the second week after the combination immunotherapy were better than those in the conventional group. Conclusion: The preliminary results show that the combination therapy can reduce or eliminate the clinical manifestations of ANP secondary infection and shorten the duration of infection.