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胃-食管反流是由酸和胃蛋白酶在胃肠道由胃至下段食管的向上运动而引起,特点是胸骨下灼痛,通常在餐后或躺卧时出现。据估计约1/3的人有反流性疾病,高达65％的人每年都会经历不同程度的胃灼热,其中许多人用非处方药物如抗酸剂治疗,但在英因每年约有500万人为此去消化科看病,其中绝大多数会接受H_2-受体拮抗剂、西沙必利或奥美拉唑等紧急药物治疗。但是许多患者在紧急治疗结束后反流症状又复发,治疗后第一年复发率为20％～70％,而且病程严重的病人往往需要维持治疗。杨森的胃动学药物西沙必利在英国已被批
Gastroesophageal reflux is caused by the upward movement of acids and pepsin in the gastrointestinal tract from the stomach to the lower esophagus. It is characterized by burning of the sternum, usually after meal or when lying down. It is estimated that about one-third of people have reflux disease and up to 65% experience heartburn at varying degrees each year, many of whom are over-the-counter medications such as antacids. However, The Department of Gastroenterology see the doctor, most of them will receive H 2 -receptor antagonists, cisapride or omeprazole and other emergency drug treatment. However, many patients relapse after the emergency treatment of reflux symptoms, the first year after treatment, the recurrence rate was 20% to 70%, and patients with severe disease often require maintenance treatment. Janssen’s gastrokinemic drug cisapride has been approved in the UK