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目的探讨混合型注意缺陷多动障碍(CADHD)患儿外周血不饱和脂肪酸水平的变化及其临床意义。方法选取CADHD患儿和正常儿童为研究对象,采用气相色谱法检测外周血脂肪酸水平,比较两组间的差异,分析Conners量表因子及执行功能与脂肪酸的相关性。结果 CADHD组患儿在品行问题、学习问题、冲动多动、多动指数因子、A式和B式划线测验时间等方面均明显高于对照组(均P<0.05),数字背诵测验的顺背、倒背得分均明显低于对照组(P<0.05或<0.01)。CADHD组患儿外周血饱和脂肪酸高于对照组,而单不饱和脂肪酸和多不饱和脂肪酸低于对照组,其中18∶0饱和脂肪酸、花生四烯酸(AA)、二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)的差异有统计学意义(均P<0.05)。Conners量表的学习问题、冲动多动和多动指数因子及划线A式、B式与AA、EPA和DHA均成负相关(均P<0.05),顺背、倒背及记忆总分均与AA和EPA均无关(均P>0.05),与DHA成正相关(P<0.05)。结论 CADHD患儿血AA、EPA和DHA明显低于正常儿童,Conners量表的学习问题、冲动多动和多动指数因子均与AA、EPA和DHA成负相关。
Objective To investigate the changes and clinical significance of the levels of unsaturated fatty acids in peripheral blood in children with mixed-form attention deficit hyperactivity disorder (CADHD). Methods The children with CADHD and normal children were selected as study objects. The levels of fatty acids in peripheral blood were detected by gas chromatography. The difference between the two groups was analyzed. Correlation between Conners’ scale factor and executive function and fatty acids was analyzed. Results Children in CADHD group were significantly higher than those in control group in terms of conduct problems, learning problems, impulsive hyperactivity, hyperactivity index factor, type A and type B scribing time (all P <0.05) Back and back scores were significantly lower than the control group (P <0.05 or <0.01). The serum levels of saturated fatty acids in CADHD group were higher than those in control group, while the levels of monounsaturated fatty acids and polyunsaturated fatty acids were lower than those in control group, including 18: 0 saturated fatty acid, arachidonic acid (AA), eicosapentaenoic acid EPA) and docosahexaenoic acid (DHA) were statistically different (all P <0.05). Conners scale learning problems, impulsive hyperactivity and hyperactivity index factors and crossed A formula, B formula and AA, EPA and DHA were negative correlation (both P <0.05), Shun back, back and memory total score There was no correlation with AA and EPA (all P> 0.05), and was positively correlated with DHA (P <0.05). Conclusions AA, EPA and DHA in children with CADHD were significantly lower than those in normal children. The Conners scale learning problems, impulsive hyperactivity and hyperactivity index were negatively correlated with AA, EPA and DHA.