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目的:分析阿德福韦酯对乙肝的治疗效果及产生的毒副作用。方法:选择在我院接受治疗的慢性乙肝患者180例,随机分成A、B、C共3组,比较3个月后3组患者临床疗效及其毒副作用。结果:B、C组患者临床疗效明显优于A组,数据差异明显,具有统计学意义,<0.05;比较3组患者血清中肌酐及磷水平,C组患者明显高于A、B组,数据差异明显,具有统计学意义,<0.05。结论:对于乙肝患者而言,阿德福韦酯用量不宜>10mg/d,如超过,则很容易产生较大毒副作用,但过低剂量可造成无法达到令人满意的临床效果。
Objective: To analyze the therapeutic effect of adefovir dipivoxil on hepatitis B and its toxic and side effects. Methods: One hundred and eighty chronic hepatitis B patients who were treated in our hospital were randomly divided into three groups (A, B and C). The clinical efficacy and side effects of the three groups after 3 months were compared. Results: The clinical curative effect of group B and group C was better than that of group A, the data had significant difference (P <0.05). The levels of serum creatinine and phosphorus in three groups were significantly higher than those in group A and group B Significant difference, with statistical significance, <0.05. Conclusion: Adequate doses of adefovir dipivoxil should not be more than 10mg / d for patients with hepatitis B, and if it is more than 0.1mg / d, it will be easy to produce toxic side effects. However, too low doses may cause unsatisfactory clinical results.