论文部分内容阅读
血流动力学的改变对脂质沉积和血管内皮的影响与动脉粥样硬化(artherosclerosis,As)的发生密切相关。本实验以颈总动脉套管和高脂饵食法建立家兔局部低剪切应力As模型,通过检测造模2,4,8周的血流量、切应力、血脂水平及血管病理形态,发现颈总动脉套管法在近心端可形成局部低剪应力;阿托伐他汀和参莲提取物呈时间依赖性和剂量依赖性地增加近心端血流量(P<0.05),降低血清总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(lowdensity lipoprotein cholesterol,LDL-C)水平(P<0.05),减少As模型家兔近心端血管病变程度。本研究首次证实了参莲提取物(丹参和穿心莲组成)对As斑块形成的抑制作用与改善血流有关。
The effects of hemodynamic changes on lipid deposition and vascular endothelium are closely related to the development of artherosclerosis (As). In this study, local low-shear stress As model of rabbit was established by carotid artery cannulation and high-fat diet. The blood flow, shear stress, blood lipid level and pathological changes of blood vessels were detected at 2, 4, The common carotid artery cannulation method can induce local low shear stress at the proximal end of the carotid artery. Atorvastatin and Shen-lin extract can increase the proximal-cardiac blood flow in a time-dependent and dose-dependent manner (P <0.05) Total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) levels in the As model rabbits were decreased (P <0.05). This study for the first time confirmed that the extract of Salvia (Salvia miltiorrhiza and Andrographis) on As plaque formation inhibition and improvement of blood flow.