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目的 :探讨过敏性紫癜患者的血清中过敏原特异性IgE抗体和血清总IgE水平 ,了解过敏性紫癜过敏原的组成 ,为临床寻找病因和做好有效的预防提供实验室依据。方法 :采用酶免疫分析法对 40例过敏性紫癜患者 (其中单纯性紫癜 2 0例 ,胃肠型紫癜 9例 ,肾型紫癜 8例 ,关节型紫癜 3例。)检测血清过敏原特异性IgE抗体 ,同时检测血清总IgE水平。结果 :40例中血清总IgE阳性 (≥ 90IU /ml)的 3 2例 ,占 80 % ;吸入组中最高的是多价霉菌 ( 14 / 40 ) ,其次是豚草 ( 10 / 40 )、屋尘 ( 8/ 40 )、尘螨 ( 8/ 40 )、蒿属植物 ( 4 /40 )、树木花粉 ( 4 / 40 ) ;食物组中过敏原以鱼 ( 12 / 40 )为最高 ,其次是牛奶 ( 10 / 40 )、虾蟹 ( 8/ 40 )、和蛋类 ( 8/ 40 )、牛羊猪肉 ( 5 / 40 )、大豆花生 ( 3 / 40 )。结论 :酶免疫分析法对过敏性紫癜患者进行血清过敏原检测 ,发现吸入组与食物组阳性率无显著差异 ,且以混合过敏较多 ,为临床寻找相应过敏原并做好有效的预防 ,提供实验室诊断和防治依据。
Objective: To investigate the serum allergen-specific IgE antibodies and serum total IgE levels in patients with allergic purpura and to understand the composition of allergic purpura allergens to provide a laboratory basis for finding the cause of the disease and effective prevention. Methods: Enzyme immunoassay was used to detect serum allergen-specific IgE in 40 patients with allergic purpura (20 cases of simple purpura, 9 cases of gastrointestinal purpura, 8 cases of renal purpura and 3 cases of joint purpura) Antibodies were detected simultaneously with serum total IgE levels. Results: Of the 40 patients, 32 (80%) had positive serum total IgE (≥ 90IU / ml), 14/40 were the highest in the inhaled group, followed by Ragweed (10/40) (8/40), dust mite (8/40), artemisia (4/40), and tree pollen (4/40). In the food group, the highest allergen was fish (12/40), followed by milk (10/40), shrimp and crab (8/40), and eggs (8/40), beef and mutton (5/40) and soybean and peanut (3/40) respectively. Conclusion: Serum allergen was detected by enzyme-immunoassay in patients with allergic purpura. There was no significant difference between the inhaled group and the food group in allergic purpura, and there was more mixed allergy to find the corresponding allergens for clinical and effective prevention. Laboratory diagnosis and prevention basis.