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目的：探讨卡铂加不同给药途径的足叶乙甙组成的治疗方案对非小细胞肺癌的疗效及不良反应。方法：1997年5月～1999年8月，用卡铂加口服足叶乙甙方案35例与卡铂加静滴足叶乙甙方案31例对照治疗。结果：治疗组（CEoral regimen）总有效率CR＋PR为42．9％（15／35），对照组CEivd regimen为45．2％（14／31），两种不同给药途径CE方案的近期疗效无统计学差异χ2＝0．035，P＞0．10，前者中位缓解期较长（4个月／3．5个月），白细胞下降及脱发等不良反应均比对照组明显减轻（P＜0．10，P＜0．025）。结论：卡铂加口服足叶乙甙方案给药方法安全简便，血液学毒性较轻微，适合年老体弱患者的姑息性治疗。
OBJECTIVE: To investigate the efficacy and adverse reactions of carboplatin plus different doses of aconitine and acetylcholine in treatment of non-small cell lung cancer. Methods: From May 1997 to August 1999, 35 patients were treated with carboplatin plus oral etoposide and 31 patients were treated with carboplatin plus intravenous drip et al. Results: The total effective rate of CEoral regimen was 42.9% (15/35) in the treatment group, and 45.2% (14/31) in the control group CEivd regimen. Two different routes of administration CE The short-term efficacy was not statistically significant (χ2=0.035, P>0.10). The former had a longer remission period (4 months/3.5 months), and the adverse reactions such as leukopenia and hair loss were better than those of the control. The group was significantly reduced (P < 0.10, P <0.025). Conclusion: The method of administration of carboplatin plus oral etoposide is safe and simple, and the hematological toxicity is mild. It is suitable for palliative treatment of frail elderly patients.