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调节性T细胞(Treg)作为众所周知的具有负免疫调节功能的T细胞亚群,不仅可抑制急性缺血-再灌注损伤(IRI)中的先天性免疫,也可在肾移植术后调节免疫耐受中起着重要的作用。因此,正确认识和利用肾移植患者体内Treg分化、扩增、活性及作用机制等的影响因素,使其发挥负免疫调节功能至关重要。本文从内在生物因素、药物因素、移植肾相关因素等方面,对肾移植患者体内Treg的影响因素研究进展作一综述。
Regulatory T cells (Tregs), as a well-known subset of T cells with negative immunomodulatory functions, not only inhibit innate immunity during acute ischemia-reperfusion injury (IRI), but also regulate immune tolerance after kidney transplantation By playing an important role. Therefore, to correctly understand and make use of the influencing factors of Treg differentiation, expansion, activity and mechanism in renal transplant recipients, it is very important to exert negative immune regulation function. This review summarizes the research progress on the influential factors of Treg in renal transplant recipients from the aspects of intrinsic biological factors, drug factors and related factors of renal transplant.