论文部分内容阅读
[目的]观察云香复合胃痛胶囊治疗实验性大鼠慢性浅表性胃炎(CSG)的疗效及作用机制,为该胶囊治疗CSG的临床应用提供依据。[方法]采用水杨酸钠及饥饱失常法建立CSG大鼠模型,造模成功后,除正常组外,抽取50只随机分为5组,观察大鼠胃酸酸度、胃蛋白酶活性以及胃黏膜形态结构等的变化。[结果]模型组大鼠胃酸酸度、胃蛋白酶活性显著高于正常组,各治疗组明显低于模型组(均P<0.01)。[结论]云香复合胃痛胶囊可降低胃酸酸度、抑制胃蛋白酶活性、减少胃黏膜损伤,可能是治疗CSG的机制之一。
[Objective] To observe the therapeutic effect and mechanism of Yunxiang Compound Weitong Capsule on experimental chronic superficial gastritis (CSG) in rats, so as to provide basis for the clinical application of this capsule in the treatment of CSG. [Methods] The CSG rat model was established by sodium salicylate and hunger-satisfaction method. After successful modeling, 50 rats were randomly divided into 5 groups except for the normal group. Gastric acidity, pepsin activity and gastric mucosa were observed. Morphological changes. [Results] The gastric acidity and pepsin activity in the model group were significantly higher than those in the normal group, and each treatment group was significantly lower than the model group (all P<0.01). [Conclusion] Yunxiang Compound Weitong Capsule can reduce gastric acidity, inhibit pepsin activity and reduce gastric mucosal damage, which may be one of the mechanisms of CSG treatment.