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目的分析S-腺苷蛋氨酸对原发性肝癌介入化疗栓塞(TACE)后急性肝功能损害的保护作用。方法选择2015年1月~2017年1月我院收治的80例行TACE治疗的原发性肝癌患者作为研究对象,根据随机综合序贯法将患者分为对照组和观察组,每组40例。对照组给予常规的保肝治疗,包括TACE治疗、肝泰乐片+维生素C+肌苷注射液等药物干预。观察组在对照组基础上给予S-腺苷蛋氨酸治疗,比较两组治疗前后不同时间的肝功能指标变化。结果治疗前,两组患者肝功能指标比较,差异无有统计学意义(P>0.05);治疗后7 d,观察组肝功能指标水平低于对照组,差异有统计学意义(P<0.05);观察组治疗满意度明显高于对照组,差异有统计学意义(P<0.05)。结论在肝癌TACE后予以S-腺苷蛋氨酸静滴治疗,可有效的缓解急性肝功能损害,促进患者的肝功能恢复。
Objective To analyze the protective effect of S-adenosylmethionine on acute hepatic dysfunction after primary hepatocellular carcinoma (HACE) interventional chemoembolization (TACE). Methods A total of 80 patients with primary liver cancer who underwent TACE in our hospital from January 2015 to January 2017 were selected as subjects. The patients were divided into a control group and an observation group according to a random integrated sequential method. Each group consisted of 40 patients. . The control group was given routine hepatoprotective therapy, including TACE treatment, liver tai le tablets + vitamin C + inosine injection and other drug interventions. The observation group was treated with S-adenosylmethionine on the basis of the control group, and the changes of liver function indexes at different time before and after treatment were compared. Results Before treatment, the difference of liver function between the two groups was not statistically significant (P>0.05). At 7 days after treatment, the level of liver function in the observation group was lower than that of the control group, and the difference was statistically significant (P<0.05). The satisfaction of treatment in the observation group was significantly higher than that in the control group, and the difference was statistically significant (P<0.05). Conclusion S-adenosylmethionine intravenous infusion after hepatocellular carcinoma TACE can effectively relieve acute liver damage and promote the recovery of liver function.