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Objective: To research the contribution of ILK and PTEN to the carcinogenesis and development of gastric carcinoma and the relation with anti-oncogene PTEN. Methods: ILK and PTEN proteins, PTEN mRNA of 76 cases of normal gastric mucous and 112 cases of gastric carcinoma were detected by immunohistochemistry method and in situ hybridization. Results: The expression of ILK, PTEN protein in gastric carcinoma group and normal gastric mucosa group, muscular layer invasive group and no muscular layer invasive group, lymphatic metastasis group and non-lymphatic metastasis group were all statistical significance (P < 0.05 or P< 0.01). The expression of PTEN mRNA of gastric carcinoma group was lower than that of normal gastric mucosa group (P < 0.01). The expression of ILK and PTEN protein had negative correlation (r = -0.347, P < 0.01). Conclusion: ILK protein increasing and PTEN protein decreasing have closely relation with the genesis and develop merit of gastric carcinoma, and controlling them may become a new treating target gastric cancer.