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目的探讨中老年高尿酸血症对血管内皮功能的影响。方法对100例48-68岁经健康体检无心血管疾病或痛风者(其中50名血尿酸正常对照者,50例高尿酸血症者),应用高分辨率超声显像法检测其肱动脉血管内皮依赖性舒张功能。结果两组的肱动脉内径基础值[分别为(3．8±0．6)mm 和(3．8±0．7)mm]及含服硝酸甘油后肱动脉内径变化百分率[分别为(19±5)％和(19±6)％],差异均无统计学意义,高尿酸血症组反应性充血后肱动脉内径变化的百分率[(12±4)％]较正常对照组[(17±5)％]显著降低(P<0．01)。结论中老年高尿酸血症患者存在血管内皮功能障碍。
Objective To investigate the effect of hyperuricemia on vascular endothelial function in the elderly. Methods 100 cases of 48-68 years old without physical cardiovascular disease or gout (50 cases of normal uric acid and 50 cases of hyperuricemia), high-resolution ultrasound imaging of brachial artery endothelium Dependent diastolic function. Results The basal values of brachial artery internal diameter [(3.8 ± 0.6) mm and (3.8 ± 0.7) mm] and the percentage change of brachial artery internal diameter after oral administration of nitroglycerin [(19 ± 5% and 19 ± 6%, respectively. There was no significant difference between the two groups (P> 0.05). The percentage of brachial artery diameter in hyperuricemia group was significantly higher than that in control group [(17 ± 6)% ± 5)%] (P <0.01). Conclusion There are vascular endothelial dysfunction in middle-aged and elderly patients with hyperuricemia.