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目的探讨谷氨酰胺改善胃癌患者围手术期免疫功能的疗效。方法 77例患者随机分为两组:A组33例,给予常规围术期治疗;B组44例,加用谷氨酰胺20 g加入500 ml氨基酸注射液静脉输注,每天1次,从入院开始用至术后7 d。观察术后7 d感染发生率、胃肠功能恢复时间和免疫功能。结果 A组患者术后7 d感染发生率明显高于B组(27.3%vs.0.1%)(P<0.01),胃肠功能恢复时间长于B组[(4.2±2.2)d vs.(3.6±2.7)d](P<0.05)。与术前1 d比较,术后第7天A组患者血白蛋白I、gM降低(P<0.05),B组IgG、CD4+细胞和CD8+细胞比例升高(P<0.05)。结论谷氨酰胺可促进胃癌患者围手术期免疫功能恢复。
Objective To investigate the effect of glutamine on perioperative immune function in patients with gastric cancer. Methods A total of 77 patients were randomly divided into two groups: group A (33 cases) received routine perioperative treatment; group B (44 cases) received intravenous infusion of glutamine 20 g and 500 ml amino acid injection once daily Start to use after 7 days. The incidence of infection, gastrointestinal function recovery time and immune function were observed 7 days after operation. Results The incidence of infection after 7 days in group A was significantly higher than that in group B (27.3% vs.0.1%) (P <0.01), and the recovery time of gastrointestinal function was longer than that in group B [(4.2 ± 2.2) d vs. (3.6 ± 2.7) d] (P <0.05). Compared with the first day before operation, serum albumin I and gM in group A decreased (P <0.05), and the proportion of IgG, CD4 + and CD8 + cells in group B increased on the 7th day after operation (P <0.05). Conclusion Glutamine can promote perioperative immune function recovery in patients with gastric cancer.