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目的探讨弥漫性结缔组织疾病(CTD)与动脉粥样硬化(AS)发生发展的相关性。方法采用常规方法分别检测88例结缔组织疾病患者、69例疾病对照组患者及29例健康体检者血脂水平、血清hs-CRP和Hcy水平,对上述各指标进行统计学分析。结果1与正常对照组和疾病对照组相比,CTD患者组血清TC,TG,LDL-C水平显著增高;HDL-C水平较正常对照组显著降低(P=0.043)。2CTD患者血清hs-CRP显著高于疾病对照组(P=0.001)和正常对照组(P=0.002),且与HDL-C,ApoA1水平负相关。3CTD患者血清Hcy水平高于疾病对照组(P=0.044)与健康对照组(P=0.003),差异有统计学意义,但与血清脂质、hs-CRP无显著相关性。结论CTD患者存在严重血脂代谢紊乱,炎性指标升高,同时具有高Hcy血症。结果提示CTD与ASCVD密切相关,且为治疗CTD相关动脉粥样硬化性心血管疾病提供相应证据。
Objective To investigate the relationship between diffuse connective tissue disease (CTD) and the development of atherosclerosis (AS). Methods The levels of serum lipids, serum hs-CRP and Hcy in 88 patients with connective tissue disease, 69 patients with disease control group and 29 healthy controls were detected by routine methods. The above indexes were statistically analyzed. Results 1 Compared with the normal control group and the control group, the levels of TC, TG and LDL-C in patients with CTD were significantly higher than those in the control group (P = 0.043). The serum hs-CRP level of 2CTD patients was significantly higher than that of the control group (P = 0.001) and the normal control group (P = 0.002), and negatively correlated with the levels of HDL-C and ApoA1. The serum Hcy level of 3CTD patients was higher than that of the control group (P = 0.044) and healthy control group (P = 0.003), but there was no significant correlation with serum lipid and hs-CRP. Conclusion CTD patients have severe dyslipidemia, elevated inflammatory markers, and hyperhomocysteinemia. The results suggest that CTD and ASCVD are closely related, and provide evidence for the treatment of CTD-related atherosclerotic cardiovascular disease.