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作者报告用大剂量静脉丙球(IVGG)治疗4例自身免疫性溶血性贫血(AIHA)的结果。例1:男孩,22个月。6个月时患免疫性血小板减少性紫癜(ITP),后转为 AIHA。尽管输注压积红细胞和给予大剂量的强的松治疗6个月,仍贫血。网织红细胞计数为15—20%。15个月时,用常规剂量(5天中共2g/kg)的 IVGG 治疗,无效。继续给予大剂量 IVGG(1g/kg/天)共5天,到第8天时,血红蛋白(Hb)从7.8g/dl 上升到9.1g/dl。仍按每周2次(总剂量1g/kg)给予 IVGG 维持治疗,3个月
The authors report the results of treating 4 patients with autoimmune hemolytic anemia (AIHA) with high-dose IVGG. Example 1: Boy, 22 months. 6 months after suffering from immune thrombocytopenic purpura (ITP), later converted to AIHA. Although anemia infused red blood cells and given large doses of prednisone for 6 months, anemia was still reported. Reticulocyte count was 15-20%. At 15 months, treatment with IVGG at the usual dose (2 g / kg total over 5 days) was not effective. High doses of IVGG (1 g / kg / day) were continued for a total of 5 days and by day 8 hemoglobin (Hb) rose from 7.8 g / dl to 9.1 g / dl. IVGG maintenance treatment was also given twice a week (total dose of 1 g / kg) for 3 months