骨肉瘤是一种起源于间叶组织的原发性恶性骨肿瘤,好发于青少年,发病率约为百万分之三,恶性度高,早期易转移,对化疗易产生耐受性,预后差。目前研究证实肿瘤实质上是一种基因疾病,肿瘤的发生发展涉及多个基因的改变,包括正常基因的突变或缺失、癌基因的异常扩增和表达以及多个调节基因的协同作用,加之基因本身多效性和机体免疫因素,最终决定肿瘤表型的表达与否。 Osteosarcoma is a primary malignant bone tumor originated from mesenchymal tissue, occurs in adolescents, the incidence rate of about three millionths, high malignant, early metastasis, easy to chemotherapy tolerance, prognosis difference. The current study confirmed that the tumor is essentially a genetic disease, tumor development involves the transformation of multiple genes, including normal mutations or deletions, abnormal amplification and expression of oncogenes and the synergy of multiple regulatory genes, combined with the gene Its own pleiotropic and immune factors, and ultimately determine the expression of tumor phenotype or not.