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目的分析局部区域热疗配合化疗治疗胰腺癌的效果。方法选取胰腺癌患者52例,随机分为观察组和对照组各26例。对照组给予常规吉西他滨+顺铂全身静脉化疗方案进行治疗,观察组在对照组治疗基础上实施局部区域热疗,比较2组临床疗效。结果观察组治疗有效率为42.3%,疾病控制率为76.9%,均高于对照组的15.4%和50.0%,差异有统计学意义(P<0.05)。2组患者半年、1年内生存率比较差异无统计学意义(P>0.05);而观察组患者1年半、2年内生存率均高于对照组,差异有统计学意义(P<0.05)。2组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论局部区域热疗配合化疗可有效提高胰腺癌治疗有效率、疾病控制率及远期生存率,安全性高,具有较高的临床应用价值。
Objective To analyze the effect of regional hyperthermia combined with chemotherapy on pancreatic cancer. Methods Fifty-two patients with pancreatic cancer were randomly divided into observation group and control group with 26 cases each. The control group received conventional systemic intravenous chemotherapy with gemcitabine plus cisplatin. The observation group was treated with local hyperthermia based on the control group and compared the clinical efficacy of the two groups. Results The effective rate was 42.3% in the observation group and 76.9% in the disease control group, which was higher than that in the control group (15.4% and 50.0%). The difference was statistically significant (P<0.05). There was no significant difference in the survival rate between the two groups within six months and one year (P>0.05). In the observation group, the survival rate was one year and a half and two years higher in the observation group than in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Regional hyperthermia combined with chemotherapy can effectively improve the efficiency of treatment, disease control rate and long-term survival rate of pancreatic cancer, with high safety and high clinical application value.