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目的观察甲磺酸托烷司琼在子宫颈癌手术后恶心呕吐(postoperative nausea and vomiting,PONV)的防治效果。方法选择择期妇科子宫颈癌手术患者70例,随机分为治疗组和对照组,每组35例。两组均采用气管内插管全麻,治疗组患者术毕给予甲磺酸托烷司琼6 mg静脉注射。术后48 h内观察并评估PONV发生率及程度,记录需要止吐治疗的患者例数。结果治疗组术后PONV的发生率为20%;对照组为71%,差异有统计学意义(P<0.05)。结论术毕静脉注射甲磺酸托烷司琼可有效预防子宫颈癌手术后恶心呕吐的发生。
Objective To observe the efficacy of tropisetron mesylate in the prevention and treatment of postoperative nausea and vomiting (PONV) after cervical cancer surgery. Methods Seventy patients with elective gynecological cervical cancer were randomly divided into treatment group and control group, with 35 cases in each group. Both groups were given endotracheal intubation general anesthesia, patients in the treatment group were given intravenous injection of tropisetron 6 mg. The incidence and extent of PONV were observed and evaluated within 48 hours after operation. The number of patients requiring antiemetic treatment was recorded. Results The incidence of postoperative PONV was 20% in the treatment group and 71% in the control group, the difference was statistically significant (P <0.05). Conclusion Intravenous intravenous tropisetron mesylate can effectively prevent the occurrence of nausea and vomiting after cervical cancer surgery.