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目的:研究血管内皮生长因子(VEGF)与表皮生长因子(EGF)在肺癌患者血清中的表达及不同病理类型中的表达差异。方法:实验包括肺癌组35例,良性肺疾病组11例,健康对照组10例。用酶联免疫吸附法(ELISA)测定VEGF,放射免疫法(RIA)测定EGF。结果:肺癌组血清VEGF与EGF的水平高于良性肺疾病组和健康对照组,差异有统计学意义(P<0.05)。但VEGF与EGF表达水平与肿瘤的病理类型无关,鳞癌、腺癌和小细胞癌血清VEGF、EGF表达水平差异均无统计学意义(P>0.05)。结论:肺癌患者血清VEGF与EGF表达水平测定有助于肺癌的辅助诊断及治疗。
Objective: To investigate the expression of vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) in the serum of patients with lung cancer and the difference of expression in different pathological types. Methods: The experiment included 35 cases of lung cancer group, 11 cases of benign lung disease group and 10 cases of healthy control group. VEGF was detected by enzyme-linked immunosorbent assay (ELISA) and EGF was measured by radioimmunoassay (RIA). Results: The serum levels of VEGF and EGF in lung cancer group were significantly higher than those in benign pulmonary disease group and healthy control group (P <0.05). However, the expression of VEGF and EGF had no correlation with the pathological type of tumor. There was no significant difference in the expression of VEGF and EGF between squamous cell carcinoma, adenocarcinoma and small cell carcinoma (P> 0.05). Conclusion: The determination of serum VEGF and EGF levels in patients with lung cancer is helpful for the diagnosis and treatment of lung cancer.