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胰岛细胞移植目前已经被公认为是治疗Ⅰ型糖尿病的一个临床选择。成功的胰岛移植可以达到一个正常或接近正常的血糖控制水平和糖化血红蛋白水平,而且还不会出现胰岛素疗法经常出现的严重的低血糖反应。与胰腺移植相比,成人胰岛细胞移植更加安全,创伤性更小,手术简捷,并发症极少,并可多次重复进行。而且,通过移植前的特殊培养,未来有望实现脱离免疫抑制剂的胰岛移植。不足之处是单纯胰岛移植使接受移植的患者不得不承受免疫抑制治疗带来的一系列不良反应。而如何使移植物保持更长时间的活力和功能以更好的控制血糖,还有许多研究工作要做。本文将就近年来国内外胰岛移植的一些相关内容做一简要综述,以期能给我国移植和内分泌医师带来一定的启示。
Islet cell transplantation is now recognized as a clinical option for the treatment of type 1 diabetes. Successful islet transplantation can achieve a normal or near-normal glycemic control and glycosylated hemoglobin level without the severe hypoglycemic reaction often seen with insulin therapy. Compared with pancreas transplantation, adult islet cell transplantation safer, less traumatic, simple operation, minimal complications, and can be repeated many times. Moreover, through the special culture before transplantation, the future is expected to achieve the transplantation of islets from immunosuppressive agents. The downside is that simple islet transplantation allows transplant patients have to withstand a series of adverse reactions caused by immunosuppressive therapy. How to make the graft longer vitality and function to better control blood sugar, there are many research work to do. This article will give a brief overview of some related contents of islet transplantation at home and abroad in recent years, with a view to bring some enlightenment to our transplant and endocrinology physicians.