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目的:研究抗焦虑抑郁治疗方法对原发性高血压合并焦虑抑郁患者血压的影响。方法:纳入在潮州市中心医院心内科病房及门诊就诊100例原发性高血压合并焦虑抑郁患者作为研究对象,采取随机数字法分为两组,各50例,对照组予以常规降压联合安慰剂方案,试验组于其基础治疗予以度洛西汀联合地西泮方案,对比两组治疗前后焦虑抑郁评分、坐位血压疗效、动态血压、同型半胱氨酸以及CRP。结果:实验组SAS、SDS评分、d SBP、d DBP、n SBP、n DBP、同型半胱氨酸、CRP均显著低于对照组,且坐位血压疗效总有效率显著高于对照组(96%比80%,P<0.05)。结论:在常规降压基础上予以度洛西汀以及地西泮进行抗焦虑抑郁治疗,可对原发性高血压合并焦虑抑郁患者产生显著疗效,获得良好降压效果,应用价值高。
Objective: To study the effects of anti-anxiety and depression treatment on blood pressure in patients with essential hypertension and anxiety and depression. Methods: A total of 100 patients with primary hypertension and anxiety and depression attending Cardiology Department of Chaozhou Central Hospital were enrolled in this study. Patients were randomly divided into two groups (n = 50). The control group The experimental group was given duloxetine plus diazepam in its basic treatment. The anxiety and depression scores, sitting blood pressure response, ambulatory blood pressure, homocysteine and CRP were compared between the two groups before and after treatment. Results: The scores of SAS, SDS, d SBP, d DBP, n SBP, n DBP, homocysteine and CRP in the experimental group were significantly lower than those in the control group, and the total effective rate of sitting blood pressure was significantly higher than that of the control group (96% Than 80%, P <0.05). Conclusion: Duloxetine and diazepam can be used to relieve anxiety and depression in patients with essential hypertension and anxiety and depression, and the antihypertensive effect of duloxetine and diazepam can be obtained with good antihypertensive efficacy and high application value.