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目的:分析研究IgA肾病组织的病理学特点与临床预后的关系,提高对该病的进一步认识。方法:选取2011年1月至2015年8月期间我院肾内科收治的IgA肾病患者86例作为研究对象,经肾穿刺取活检组织并行光镜检查、电镜检查及免疫荧光等检查,其病理结果按照Lee氏分级,认真分析其临床特征、临床疗效及预后等。结果:病理结果较轻患者多表现为蛋白尿或无症状血尿,疗效及预后均相对较好;而病理结果较重患者多表现为肾功能不全及肾病综合征伴高血压。Ⅰ-Ⅱ级患者治疗有效率为66.7%,Ⅲ级及以上患者治疗有效率为25.0%。结论:早期行肾穿刺活检并治疗,能够控制Igh肾病患者肾功能衰竭的发展。
Objective: To analyze the relationship between the pathological features of IgA nephropathy and clinical prognosis, and to improve the understanding of the disease. Methods: Totally 86 patients with IgA nephropathy admitted to Department of Nephrology of our hospital from January 2011 to August 2015 were enrolled in this study. The pathological results were examined by light microscopy, electron microscopy and immunofluorescence after renal biopsy, According to Lee’s classification, careful analysis of its clinical features, clinical efficacy and prognosis. Results: The pathological results of patients with mild proteinuria or asymptomatic hematuria, the curative effect and prognosis are relatively good; and pathological results were more severe in patients with renal insufficiency and nephrotic syndrome with hypertension. The effective rate of Ⅰ-Ⅱ patients was 66.7%, and that of Ⅲ-level and above patients was 25.0%. Conclusion: Early renal biopsy and treatment can control the development of renal failure in patients with Igh nephropathy.