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研究目的 探讨儿童单纯性肾病肾上腺皮质功能低下的治疗方法及其临床意义。 研究方法 39例患儿(男31例,女8例)随机分为两组,治疗组(用强的松、黄芪和刺五加治疗)21例,对照组(只用强的松治疗)18例。每例患儿于治疗前后晨8时各抽血1ml,用放射免疫分析法测定血清皮质醇含量。 研究结果 在对照组,治疗后血清皮质醇含量仍然低于正常水平,大剂量激素治疗后,测定值较前又显著降低。黄芪、刺五加与激素联合治疗组,治疗后血清皮质醇水平恢复正常。 研究结论 黄芪和刺五加能纠正单纯性肾病患儿肾上腺皮质功能低下,减少复发。
Objective To investigate the treatment of adrenal insufficiency in children with simple nephropathy and its clinical significance. Methods Thirty-nine children (31 males and 8 females) were randomly divided into two groups. The treatment group (21 cases treated with prednisone, astragalus and acanthopanax), the control group (prednisone only) example. Each child in the morning before treatment at 8 am each blood draw 1ml, radioimmunoassay measured serum cortisol content. The results in the control group, after treatment serum cortisol levels are still below normal levels, high-dose hormone treatment, the measured value was significantly lower than before. Astragalus, Acanthopanax and hormone combined treatment group, serum cortisol levels returned to normal after treatment. Conclusions Astragalus and Acanthopanax can correct adrenal insufficiency and reduce relapse in children with simple nephropathy.