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目的评价单侧苍白球腹后部毁损术对两种不同类型的帕金森病的近期和远期疗效。方法应用做电极导向技术对46例帕金森病患者实施了单侧苍白球腹后部毁损术,其中震颤型20例和僵直迟缓型26例。采用“关状态”UPDRSⅢ评分对术后1月和术后1年的患者进行疗效评价并分析结果。结果单侧苍白球腹后部毁损术对两组患者运动症状的近期改善率平均为59%和56%,经一年随访分别下降为54%和17%。结论单侧苍白球腹后部毁损术稳定地改善震颤型帕金森病,而对僵直迟缓型帕金森病的疗效不稳定,远期疗效较差。
Objective To evaluate the short-term and long-term effects of unilateral globus-pallidotomy on the two different types of Parkinson’s disease. Methods 46 patients with Parkinson’s disease were treated with electrode-guided technique for the unilateral pallidotomy, including 20 cases of tremor type and 26 cases of delayed and stiff type. The “Off State” UPDRS III score was used to evaluate the efficacy of 1 month after surgery and 1 year after operation, and the results were analyzed. Results The unilateral pale bulbar posterior lesion performed an average of 59% and 56% improvement in motor symptoms for both groups, down 54% and 17% respectively after one year of follow-up. Conclusions Unilateral parvocaval abdomen injury can improve the tremor-like Parkinson’s disease steadily, but its effect on stiffness-retarding Parkinson’s disease is unstable and its long-term curative effect is poor.